One-Carbon Metabolism: The Power of Folate
Understanding the Foundation of Life
One-carbon metabolism is a fundamental biochemical process that underpins numerous biological functions, from DNA synthesis and repair to energy production and neurotransmitter synthesis. At the heart of this intricate pathway lies folate, a B-vitamin essential for optimal health.
The Role of Folate in One-Carbon Metabolism
Folate, in its various forms, plays a pivotal role in the one-carbon metabolism pathway. It acts as a carrier of one-carbon units, which are crucial for a variety of biochemical reactions. These reactions include:
DNA methylation: A process that regulates gene expression.
Amino acid synthesis: Essential for protein production.
Neurotransmitter synthesis: Influencing mood, memory, and cognitive function.
Methyl Folate: A Key Player
Methyl folate, a specific form of folate, is particularly important for DNA methylation. It provides the methyl groups necessary for this process, which is essential for normal cell growth and development.
The Future of Methyl Folate
The increasing understanding of one-carbon metabolism and the role of folate has opened up new avenues for research and clinical applications. Methyl folate, in particular, is emerging as a promising therapeutic agent for various health conditions, including:
Neurological disorders: Such as Alzheimer's disease and depression
Cardiovascular disease: By reducing homocysteine levels
Cancer: By supporting DNA repair and immune function
One-carbon metabolism is a complex but vital process that relies on folate. By understanding the role of folate, especially methyl folate, we can unlock the potential to improve human health. As research continues to advance, we can expect to see even more innovative applications of this essential nutrient.
Metafolin® has more than 25 successfully conducted clinical trials, and over 50 publications from human studies in peer reviewed journals
DISCOVER WHY YOU DON’T FEEL THE WAY YOU WANT
Discover your body’s deficiencies
The time has come to decode your genes, or, to put it plainly, to find out which genes are working as they should and which are not.
✅ Our genetic test offers the most comprehensive analysis of your current well-being based on 5 most important genes for DNA synthesis.
✅ We analyze your major actionable genes to reveal how they are impacting your day-to-day health and function.
This analysis is based specifically on your individual genetic makeup. With just one test, you will gain a clear understanding of how your genes function, identify areas requiring improvement, and receive a personalized roadmap for optimizing your health.
44% of the world’s population has this genetic mutation.
Most common symptoms of nutrient deficiencies
| Anxiety |
Poor sleep |
Thyroid problems |
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Depression |
Gut issues |
High blood pressure |
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ADD/ADHD |
Weight gain |
Bad temper |
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OCD |
Brain fog |
Age Faster |
Are you ready to truly understand your body? This could be your opportunity to discover what's really happening beneath the surface.
But first, let's discuss something you might not be aware of… Did you know that a remarkable 44% of the world's population carries a genetic mutation that makes it difficult for them to produce sufficient amounts of the 5-MTHFR enzyme?
Simply put, this means your body may not be working as efficiently as it could be. The methylation cycle is a vital process that your body uses to transform raw nutrients into usable forms. This process is essential for a wide range of functions, from detoxification and energy production to hormone balance and maintaining healthy immune and nervous system function.
However, it's important to understand that it's not just one gene that can cause problems. There are actually five key genes that can be mutated, potentially preventing your body from operating at its peak and depriving it of the essential nutrients it needs.
YOUR SYMPTOMS DON'T HAVE TO DEFINE YOUR LIFE
While we can't alter the genes you were born with, we can significantly improve how those genes function.
Did you know that absolutely everything you ingest—from proteins, carbohydrates, amino acids, and fats to minerals, nutrients, and vitamins—must be converted into a usable format for your body to benefit? Your body is capable of converting some of these compounds, but unfortunately, not all of them.
If your body lacks the ability to convert a particular nutrient, you're left with a deficiency, which can lead to a variety of health issues. And if these deficiencies aren't addressed effectively and promptly, they can accumulate over time, eventually becoming difficult to manage.
If your goal is to enhance your well-being or achieve a higher level of wellness, then taking this test is absolutely essential. The great news is that you only need to take it once in your lifetime. Are you ready to take charge of your wellness and reclaim your health? The choice is yours.
Why Do Some People Age Faster?
Some individuals age prematurely due to certain genes malfunctioning, causing cells to age faster than they should.
What is a Methylation Test?
A Methylation Test analyzes your DNA to assess the efficiency of genes involved in folate metabolism. Folate metabolism is the process of transferring "methyl" molecules from dietary folate (vitamin B9) to your DNA.
Why is Methylation Important?
"Methyl" molecules are crucial for cellular functions, such as regulating gene expression and controlling DNA activity. Efficient DNA methylation is essential for overall cellular health. By understanding your genetic makeup, you can select the most suitable supplements to slow down cellular aging.
The Methylation Process The process of transferring "methyl" molecules from dietary folate to DNA involves multiple steps:
- Dietary folate is converted into methylfolate (active form).
- The "methyl" molecule is transferred from methylfolate to vitamin B12, then to methionine, SAM, and finally to DNA.
Methylation tests may provide valuable information for individuals experiencing:
- Cardiovascular disease
- Psychiatric and mood disorders, including depression, anxiety, schizophrenia, bipolar disorder, and autism
- Impaired detoxification, whether due to toxin exposure, hormone therapy, or alcohol consumption
- Chronic fatigue
- Cognitive decline
- Increased cancer risk
In the report, you will receive results of how well your methylation pathway is working based on these 5 genes:
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MTHFR: This gene provides instructions for producing the MTHFR enzyme, essential for converting folate (vitamin B9) into its active form, 5-MTHF. Disruptions in this process can lead to folate deficiency, impacting mood, energy, digestion, and overall health. Additionally, the MTHFR enzyme aids in metabolizing homocysteine. Elevated homocysteine levels can damage blood vessel linings.
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MTR: This gene directs the production of the methionine synthase (MS) enzyme, crucial for converting homocysteine into methionine. It Involved in transferring methyl from methylfolate to methionine. This conversion relies on methylated B12. Genetic variations in MTR can impair homocysteine metabolism, increasing the risk of heart disease, dementia, digestive problems, and cancer.
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MTRR: This gene guides the production of methionine synthase reductase (MSR), an enzyme vital for the proper function of MS. It involved in transferring methyl from methylfolate to vitamin B12. Together, these enzymes work to convert homocysteine into methionine. Consequently, MTRR gene variants can also lead to elevated homocysteine levels, associated with depression, high blood pressure, Parkinson's disease, and other health issues.
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COMT: This gene provides instructions for producing the catechol-O-methyltransferase (COMT) enzyme, responsible for metabolizing neurotransmitters like dopamine and epinephrine. It is related to cellular utilization of methyl from SAM to regulate neurotransmitters. The COMT enzyme plays a crucial role in the prefrontal cortex, the brain region involved in emotions, planning, and self-control. Variations in this gene are linked to an increased risk of behavioral problems and psychiatric disorders.
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AHCY: This gene provides instructions for producing the S-adenosylhomocysteine hydrolase (AHCY) enzyme. AHCY plays a crucial role in the methionine cycle by breaking down S-adenosylhomocysteine (SAH), a byproduct of various cellular processes, including DNA methylation. It is essential for transferring methyl from homocysteine to methionine. Variations in the AHCY gene can disrupt this process, potentially impacting cellular function and contributing to various health conditions.
How to Get Tested
A Methylation Test can be easily done at home. Simply collect a saliva sample using the test kit and send it to LIVMORE with a pre-paid envelope, where you can drop off at the Post Office or by Grab. We will then send your DNA to be analyzed in a US laboratory. You will receive your results within 3 weeks.
Benefits of the Test
By understanding your unique genetic makeup, you can create a personalized health plan and select the most appropriate LIVMORE supplements to support your cellular health.
Unlock Your Health's Potential with Methylfolate
Experience the Power of Bioactive Folate
Clinical studies prove Methylfolate (Metafolin®) enhances vital organ function, promoting healthy aging from the inside out. Unlike regular folic acid, Methylfolate is a bioactive form of folate your body can use immediately, maximizing its benefits.
Key Benefits:
- Anti-Aging: Supports efficient cell function through optimal DNA methylation and gene expression.
- Brain Health: May help prevent dementia and Alzheimer's, and reduce stroke risk.
- Heart Health: Contributes to reducing heart disease and diabetes risk.
- Maternal & Infant Health: Crucial for preventing neural tube defects (NTDs) and reducing diabetes risk during pregnancy.
- Mood & Stress: Helps maintain balanced neurotransmitters (Dopamine and Adrenaline) for a more positive mood and reduced anxiety and stress.
The Methylfolate Advantage:
Methylfolate acts as a vital messenger, delivering methyl molecules to your DNA. This precise control over gene activation and deactivation ensures optimal cell function.
Because your body doesn't need to convert Methylfolate, it's significantly more effective than regular folic acid, especially considering that many people (especially 40% of Asians) have MTHFR gene variations that limit their ability to process folic acid efficiently.
Excess folic acid that your body can't process can lead to Unmetabolized Folic Acid (UMFA), which can negatively impact immune function and nervous system health.
Specifically for Expectant and Nursing Mothers:
Prioritize your health and your baby's development with our specially formulated Methylfolate supplement. This essential nutrient is crucial throughout preconception, pregnancy, and breastfeeding, periods when nutritional needs dramatically increase. Our formula is designed to meet these unique needs, supporting both mother and baby every step of the way.
Benefits at Each Stage:
- Preconception: Provides vital nutrients from the moment of conception.
- First Trimester: Supports healthy brain and spinal cord development with bioactive 5-MTHF.
- Third Trimester: Provides essential nutrients for continued fetal development and prepares mother and baby for childbirth.
- Postpartum & Breastfeeding: Supports increased dietary needs and reduces the risk of postpartum blues.
Recommended Daily Dosage (WHO Guidelines):
- Breastfeeding Mothers: 600 mcg/day (Supports baby's development and reduces postpartum blues)
- Pregnant Women: 500 mcg/day (Supports baby's development and prevents NTDs)
- Adults (14+): 400 mcg/day (For optimal DNA and cell function)
- Children (9-13): 300 mcg DFE
- Children (4-8): 200 mcg DFE
- Children (1-3): 150 mcg DFE
Directions for Use: Take 1 tablet daily (200 mcg) or as directed by your healthcare professional.
Order yours today and experience the difference!